教授、博士生导师、湖北省重点人才计划入选者
教育经历
2007/09-2012/12，武汉大学，博士
2003/09-2007/06，华中农业大学，学士
工作经历
2024/04-至今：湖北工业大学生命科学与健康工程学院，教授
2018/05-2024/04：美国弗吉尼亚大学医学院，免疫、炎症与再生中心，研究员
2013/06-2018/05：美国弗吉尼亚大学医学院，免疫、炎症与再生中心，副研究员
研究方向
1) T细胞自身免疫发生机制
2) 免疫干预分子的筛选与鉴定
基本信息
赵震环，男，武汉大学微生物专业博士学位。弗吉尼亚大学研究员，先后参与超过1000万美元的美国国立卫生研究院项目。长期担任Frontier in Cellular & infection Microbiology客座编辑，Frontiers in Nutrition以及Frontier in Immunology审稿人。2023年入选湖北省重点人才计划。现任湖北工业大学特聘教授。
主要从事自身免疫疾病中T细胞的功能与机制研究，特别是狼疮肾炎中自免疫T细胞识别自身抗原与协助自身抗体生产的功能与机制研究。以第一作者在风湿病学顶刊Annals of the Rheumatic Diseases上发表两篇研究型论文。在其他高水平杂志如Clin Immunol，J Biol Chem以及Antimicrob Agents Chemother上发表研究型论文共8篇，谷歌引用超过600次。发表在Annals of the Rheumatic Diseases上的研究型论文‘Nature of T cell epitopes in lupus antigens and HLA-DR determines autoantibody initiation and diversification’被风湿病狼疮领域权威Robert Winchester教授在同期杂志上进行了专题评论，认为该研究推动了学界对狼疮自身免疫反应起源的认识。
代表性学术论文和专著
1) Zhao Z, Anderson AN, Kannapell CC, Kwok WW, Gaskin F, Fu SM. HLA-DR3 restricted environmental epitopes from the bacterium Clostridium tetani have T cell cross-reactivity to the SLE-related autoantigen SmD. Front Immunol. 2022 Oct 31;13:928374. doi: 10.3389/fimmu.2022.928374. PMID: 36389825; PMCID: PMC9659850
2) Zhao Z, Xu B, Wang S, Zhou M, Huang Y, Guo C, Li M, Zhao J, Sung SJ, Gaskin F, Yang N, Fu SM. Tfh cells with NLRP3 inflammasome activation are essential for high-affinity antibody generation, germinal centre formation and autoimmunity. Annals of the Rheumatic Diseases. 2022 Jul;81(7):1006-1012. doi: 10.1136/annrheumdis-2021-221985. Epub 2022 Apr 12. PMID: 35414518; PMCID: PMC9262832.
3) Zhao Z, Ren J, Dai C, Kannapell C, Wang Q, Gaskin F, Fu SM. Nature of T cell epitopes in lupus antigens and HLA-DR determines autoantibody initiation and diversification. Annals of the Rheumatic Diseases. Published Online First: 25 September 2018.doi:10.1136/annrheumdis-2018-214125. (Editorials Comment by Winchester R. What structures are seen by a T cell in the immune response to a lupus autoantigen? Annals of the Rheumatic Diseases 2019;78:291-292.)
4) Zhao Z, Qiao H, Ge Y, Kannapel CC, Sung SJ, Gaskin F, Tung KSK, Fu SM. Autoimmune experimental orchitis and chronic glomerulonephritis with end stage renal disease are controlled by Cgnz1 for susceptibility to end organ damage. Clin Immunol. 2021 Mar;224:108675. doi: 10.1016/j.clim.2021.108675. Epub 2021 Jan 19. PMID: 33482358.
5) Zhao Z, Ren J, Dai C, Kannapell C, Wang Q, Gaskin F, Fu SM. HLA-DR3 Restricted T Cell Response to Smd and Ro60 Reveals Multiple Cross-Reactive Intra- and Inter-Molecular T Cell Epitopes: Unique Antigenic Structures of Lupus-Related Auto-Antigens and the Basis for B Cell Epitope Spreading [abstract]. Arthritis Rheumatol.2016; 68 (suppl 10). http://acrabstracts.org/abstract/hla-dr3-restricted-t-cell-response-to-smd-and-ro60-reveals-multiple-cross-reactive-intra-and-inter-molecular-t-cell-epitopes-unique-antigenic-structures-of-lupus-related-auto-antigens-and-the-basis/. Accessed January 20, 2017.（会议摘要）
6) Zhao Z, Ren J, Dai C, Kannapell C, Wang Q, Gaskin F, Fu SM. HLA-DR3 Restricted Response to Lupus-Related Auto-Antigen Smd: Autoreactive T Cells Are Inherent in Normal Immune Repertoires [abstract].Arthritis Rheumatol.2016; 68 (suppl 10). http://acrabstracts.org/abstract/hla-dr3-restricted-response-to-lupus-related-auto-antigen-smd-autoreactive-t-cells-are-inherent-in-normal-immune-repertoires/. Accessed January 20, 2017.（会议摘要）
7) Fu SM, Sung SJ, Wang H,Zhao Z, Gaskin F. Chapter 35 - Mechanisms of renal damage in systemic lupus erythematosus, Editor(s): George C. Tsokos, Systemic Lupus Erythematosus (Second Edition), Academic Press, 2021, Pages 313-324, ISBN 9780128145517, https://doi.org/10.1016/B978-0-12-814551-7.00035-0. (论著)
