职 称:副教授
学 历:博士
E-mail:huhan1379@163.com
研究方向:CAR-T细胞免疫治疗与应用;溶瘤病毒抗肿瘤分子机制研究;抗肿瘤多肽类药物的临床前研究
工作经历:
胡翰,博士,湖北工业大学,硕士研究生导师。美国马里兰大学医学院(University of Maryland School Of Medicine, UMSOM)公派联合培养博士。目前发表SCI论文十余篇,其中第一作者(含共同第一作者)论文9篇。主持细胞调控与分子药物“111”引智基地青年学者项目等,参与国家重大新药创制计划、国家自然科学基金项目等。
2017至今湖北工业大学讲师
2016-2017华中科技大学同济医学院附属同济医院助理研究员
研究课题:
1、重组II型溶瘤单纯疱疹病毒(OH2)联合CAR-T体内体外抗实体瘤活性研究
2、聚-β氨基酯介导的溶瘤病毒靶向治疗B淋巴细胞瘤
3、Intratumoral Treatment of Human α-defensins with Oncolytic Herpes Simplex Virus 2 (OH2) Mediate Antitumor Immunity in Mice
4、产酚类微生物的筛选及应用研究子课题
研究成果:
主要研究成果:
1. Hu Han, Di B, Tolbert WD, Gohain N, Yuan W, Gao P, Ma B, He Q, Pazgier M, Zhao L: Systematic mutational analysis of human neutrophil α-defensin HNP4. Biochimica et BiophysicaActa (BBA)-Biomembranes, 2019. 1861(4):835-844. DOI: 10.1016/j.bbamem.2019.01.007;
2. Yang Wang#, Xiaobing Zhou#, Zhen Wu#,Han Hu#, Jing Jin#,Yanping, Yuting Dong,Jianwen Zou,Zeyong Mao,Xiaotai Shi, Yan Huo,JianjunLyu, Zhizheng Fang, Wen Zhang,Yujie Zhu, Bo Li*,Binlei Liu*. Preclinical SafetyEvaluation of Oncolytic Herpes Simplex Virus Type 2, Human gene therapy,2019.30(5):651-660. DOI: 10.1089/hum.2018.170;
3. Hu, Han#, Zhang, Z. #, Wang, R., Wang, Y., Jin, J.,Cai, L. et al. (2020). BGC823 Cell Line with the Stable Expression of iRFP720 Retains Its Primary Properties with Promising Fluorescence Imaging Ability.Dna Cell Biol,2020.39(5):900-908.doi: 10.1089/dna.2019.5057
4. Hu Han, Guo N, Chen SH, Guo XZ, Liu XL, Ye SY, Chai QQ, Wang Y, Liu BL, He QG*. Antiviral activity of Piscidin 1 againstpseudorabies virus both in vitro and in vivo.Virology Journal. 2019,16(1):95. DOI : 10.1186/s12985-019-1199-4;
5. Cai, L. #, Hu, Han#., Duan, H., Li, Y., Zou, Z.,Luo, K. et al. (2020). The construction of a new oncolytic herpes simplex virus expressing murine interleukin-15 with gene editing technology. J Med Virol, 10-1002.
6. Hu Han, Wang C, Guo X, Li W, Wang Y, He Q*. Broad activity against porcine bacterial pathogensdisplayed by two insect antimicrobial peptides moricin and cecropin B. Molecules and cells,2013, 35: 106-114