职 称：讲师
学 历：博士
E-mail:zhao@hbut.edu.cn
研究方向：酶工程、生物转化
工作经历：
2010.9–2014.6 中南林业科技大学 学士 生物工程
2014.9–2020.7 华南理工大学 硕士/博士 生物工程/发酵工程
2020.8–至今 湖北工业大学 讲师
研究课题：
1.脂质分子重构制备内酯类风味化合物的酶学基础研究（31930084），国基自然科学基金重点项目，2020-2024，参与
2.海洋脂类与糖类转化酶的研制与产业化（GDOE[2019]A20）,广东省促进经济高质量发展专项资金海洋经济发展项目，2019-2021，参与
3.多酶级联转化家禽羽毛生成高附加值非蛋白氨基酸的研究，湖北工业大学科研启动基金项目，2021-2023，主持
4.细菌脂肪酶I.7家族位置选择性调控机制研究，发酵工程教育部重点实验室开放基金青年项目，2021-2023，支持
研究成果：
1. Zexin Zhao#, Shulin Hou#, Dongming Lan, Xiumei Wang, Jingsong Liu, Faez. Iqbal Khan, Yonghua Wang*, Crystal structure of a lipase from Streptomyces sp. Strain w007 - implications for thermostability and regiospecificity. FEBS Journal, 2017, 284 (20), 3506-3519.
2. Zexin Zhao, Dongming Lan, Xiyu Tan, Frank Hollmann, Uwe T. Bornscheuer, Bo Yang, Yonghua Wang*, How to break the janus effect of H2O2 in biocatalysis? Understanding inactivation mechanisms to generate more robust enzymes. ACS Catalysis, 2019, 9 (4), 2916-2921.
3. Daoming Li, Faez Iqbal Khan, Zexin Zhao, Weifei Wang, Bo Yang, Yonghua Wang*, Diacylglycerol production by genetically modified lipase from Malassezia Globosa. Journal of Molecular Catalysis B: Enzymatic, 2016, 133, S204-S212.
4. Dongjuan Yuan, Zexin Zhao, Xiumei Wang, Shaohua Guo, Bo Yang, Yonghua Wang*, Sequence-based proline incorporation improves the thermostability of Candida Albicans lipase lip5. European Journal of Lipid Science and Technology, 2016, 118 (5), 821-826.
5. Faez Iqbal Khan, Dongming Lan, Rabia Durrani, Weiqian Huan, Zexin Zhao, Yonghua Wang*, The lid domain in lipases: Structural and functional determinant of enzymatic properties. Frontiers in Bioengineering and Biotechnology, 2017, 5 (16).
6. Fanghua Wang, Hui Zhang, Zexin Zhao, Ruixia Wei, Bo Yang, Yonghua Wang*, Recombinant lipase from Gibberella Zeae exhibits broad substrate specificity: A comparative study on emulsified and monomolecular substrate. International Journal of Molecular Sciences, 2017, 18 (7), 1535.
7. Ruipu Xin, Faez Iqbal Khan, Zexin Zhao, Zedong Zhang, Bo Yang, Yonghua Wang*, A comparative study on kinetics and substrate specificities of phospholipase a1 with Thermomyces Lanuginosus lipase. Journal of Colloid and Interface Science, 2017, 488, 149-154.
8. Yanhua Liu, Dongjuan Yuan, Zexin Zhao, Dongming Lan, Bo Yang, Yonghua Wang*, A novel strategy to improve the thermostability of Penicillium Camembertii mono- and di-acylglycerol lipase. Biochemical and Biophysical Research Communications, 2018, 500 (3), 639-644.
9. Weiqian Huang, Dongming Lan, Grzegorz M. Popowicz, Krzysztof M. Zak, Zexin Zhao, Hong Yuan, Bo Yang, Yonghua Wang*, Structure and characterization of Aspergillus Fumigatus lipase b with a unique, oversized regulatory subdomain. FEBS Journal, 2019, 286 (12), 2366-2380.
10. Wei Tang, Dongming Lan, Zexin Zhao, Shuang Li, Xiuting Li, Yonghua Wang*, A thermostable monoacylglycerol lipase from marine Geobacillus sp. 12amor1: Biochemical characterization and mutagenesis study. International Journal of Molecular Sciences, 2019, 20 (3), 780.
11. Xiumei Wang, Xiaoli Qin, Xiuting Li, Zexin Zhao, Bo Yang, Yonghua Wang*, Insight into the modification of phosphatidylcholine with n-3 polyunsaturated fatty acids-rich ethyl esters by immobilized mas1 lipase. Molecules, 2019, 24 (19), 3528.
12. Xiumei Wang, Xiaoli Qin, Xiuting Li, Zexin Zhao, Bo Yang, and Yonghua Wang*, An efficient synthesis of lysophosphatidylcholine enriched with n-3 polyunsaturated fatty acids by immobilized MAS1 lipase. Journal of Agricultural and Food Chemistry, 2020, 68(1), 242-249.
13. Long Xu, Zexin Zhao, Yun-an Huang and Qiujin Zhu*,Preparation of Chitosan Molecularly Imprinted Polymers and the Recognition Mechanism for Adsorption of Alpha-Lipoic Acid. Molecules, 2020, 25(2), 312.
14. Xiumei Wang, Xiaoli Qin, Xiuting Li, Zexin Zhao, Bo Yang, and Yonghua Wang*Properties of immobilized MAS1-H108A lipase and its application in the efficient synthesis of n-3 PUFA-rich triacylglycerols. Bioprocess and Biosystems Engineering, 2020, 44, 575–584.
15.谭熙钰,赵泽鑫,杨博,王永华*. TLL脂肪酶C末端修饰对其底物选择性的调节作用.现代食品科技, 2018, 34(11): 21-27.
